Druginduced interstitial lung disease dild can be caused by chemotherapeutic agents, antibiotics, antiarrhythmic drugs, and immunosuppressive agents. Druginduced pulmonary disease msd manual professional edition. Many types of lung injury can result from medicines. Drug induced pulmonary parenchymal disease dippd can be caused by a variety of agents, including antibiotics, chemotherapeutic drugs, antiarrhythmic agents and nonsteroidal antiinflammatory. Pathologic characteristics of druginduced lung disease.
Many drugs have been associated with pulmonary complications of various types, including interstitial inflammation and fibrosis, bronchospasm, pulmonary edema, and pleural effusions. Lightchain deposition disease, neurofibromatosis, marfan syndrome, and other dclds radiation induced pneumonitis and fibrosis drug induced interstitial lung disease pulmonary alveolar proteinosis constrictive bronchiolitis idiopathic and toxic exposure induced. Nevertheless, patients with all of these conditions are prone to bouts of deterioration, resulting in respiratory compromise. A human disease model of drug toxicityinduced pulmonary. Learn which are most commonly implicated in lifethreatening pulmonary reactions in this article.
Drug induced pulmonary diseases chapter 21 interstitial lung disease pulmonary fibrosis 359 coralynn b. Drug induced pulmonary diseases by vishwanath gouda 1st year m. Air is breathed in through the nasal passageways, travels through the trachea and bronchi to the lungs. These include both cytotoxic and noncytocytoxic drugs. Druginduced lung disease dild carries a significant morbidity and mortality. Druginduced pulmonary diseases types, symptoms and treatment. Identifying this problem, and stopping the drug is the key intervention.
Sep 22, 2007 among the more common clinical manifestations of drug induced lung disease are noncardiogenic pulmonary edema npe and acute respiratory distress syndrome ards. Drug induced pulmonary disease is defined as any lung disease caused by a drug or medication 3. School of pharmacy and drug topics continuing education abstract drug induced pulmonary disease is a potential adverse effect associated with a number of medications, most notably amiodarone and bleomycin. The manifestations of drug induced pulmonary diseases span the entire spectrum of pathophysiologic conditions of the respiratory tract. Quizlet flashcards, activities and games help you improve your grades. Druginduced pulmonary disease pulmonary disorders merck. Druginduced pulmonary disease due to nonchemotherapeutic. Some drugs or therapeutic agents cause undesirable reactions in the lungs known as druginduced pulmonary diseases,which sometimes could be serious enough to cause. Druginduced pulmonary disease information mount sinai. Clinical scenarios relevant to the surgical pathologist pulmonary drug reactions result from either direct or indirect effects of a drug. Drug induced pulmonary disease is lung disease brought on by a bad reaction to a medicine. Failure to recognize druginduced pulmonary vascular disease can lead to significant morbidity and, in some cases, death.
Considering the physiologic and metabolic capacity of the lung, it is surprising that drug induced pulmonary disease is not more common. Several different respiratory adverse effects have been identified. There are two mechanisms involved in dild, which are probably interdependent. Indirect effects include drug induced thrombocytopenia, central ner. Recognition of druginduced pulmonary disease and management.
Pulmonary disease certification examination blueprint purpose of the exam the exam is designed to evaluate the knowledge, diagnostic reasoning, and clinical judgment. Druginduced pulmonary vascular diseasemechanisms and. Druginduced pulmonary disease pulmonary disorders msd. Breathing problems from drug induced pulmonary fibrosis can come on suddenly or develop more slowly over time. Full text get a printable copy pdf file of the complete article 2. Drug induced interstitial lung disease pubmed central pmc. Less common patterns of pulmonary parenchymal injury by drugs include bronchiolitis obliterans and a pulmonary renal syndrome. Diagnosing druginduced pulmonary disease remains a challenge for all pulmonologists. Therefore, the diagnosis is often difficult and, in most cases, is based on exclusion of all other possible causes. It is usually impossible to predict who will develop lung disease from a medicine. If a drug has caused fibrosis, people often get better quickly if the medication is stopped before much damage is done. As with most drug induced diseases, the pathological changes are nonspecific. Druginduced disease of any system in the body is associated with a high degree of morbidity or mortality. Oct 19, 2017 druginduced pulmonary diseases can be present in a variety of syndromes, clinical presentations and radiographic patterns.
Shaeer druginduced pulmonary disease study guide by mlabossi7 includes 34 questions covering vocabulary, terms and more. Common clinical syndromes associated with drug induced pulmonary parenchymal disease include 1 pneumonitisfibrosis, 2 hypersensitivity lung disease, and 3 noncardiogenic pulmonary edema. Drug induced interstitial lung disease pulmonary alveolar proteinosis constrictive bronchiolitis idiopathic and toxic exposure induced. A number of cardiovascular drugs have the potential to cause respiratory impairment, although diffuse parenchymal lung disease is quite rare. Treatment and outcome vary with each particular agent. Druginduced pulmonary disease is lung disease brought on by a bad reaction to a medicine. Keeping up with what is new in this field is also a challenge. So identifying this problem, and stopping the drug is the key intervention. The most common presentations of drug induced pulmonary disease are an abnormality on a chest radiograph or a symptom complex. Although many different agents may damage the lung, the patterns of cellular injury. Drug induced disease of any system or organ can be associated with high morbidity and mor tality, and it is tremendously costly to the health care of our country. Diagnostic techniques can be imprecise bronchoscopy and associated with morbidity openlung biopsy. If a drug has caused the fibrosis, people often get better quickly if the medication is stopped before much damage is done. If you merely look at pulmonary fibrosis, which is just one type of lung disease, youll find that onethird to onehalf of pf diagnoses are idiopathic, which means that the cause is unknown.
Drug and toxininduced pulmonary arterial hypertension pah is an increasingly important subgroup of group 1 pulmonary hypertension ph. Druginduced pulmonary diseases types, symptoms and. Hs3hs8 many drugs, including herbal products, have been implicated as the cause of pulmonary adverse events. Considering the physiologic and metabolic capacity of the lung, it is surprising that druginduced pulmonary disease is not more common. Drugs have long been recognized as having the potential to cause pulmonary injury. Therapeutic update on druginduced pulmonary disorders. Types of lung problems or diseases that may be caused by medicines include. The most common druginduced noncardiogenic pulmonary edema is produced by the narcotic analgesics table e304. May 31, 2012 drug induced interstitial lung disease dild is not uncommon and has many clinical patterns, ranging from benign infiltrates to lifethreatening acute respiratory distress syndrome. Druginduced pulmonary fibrosis british lung foundation. This high diagnostic hurdle is why researchers suspect that drug induced lung disease is underdiagnosed. Induced pulmonary edema in a editors summary could affect patient health. Druginduced lung disease radiology reference article.
Apr 18, 2017 pulmonary arterial hypertension pah is a subgroup of ph patients characterized hemodynamically by the presence of precapillary ph, defined by a pulmonary artery wedge pressure pawp. Everything you need to know about druginduced pulmonary. The next step is to hook this lung up to other chipbased. Causes of the latter include infection, pulmonary hypertension, and drug induced lung disease. Drug induced lung disease can result from a number of agents and may have a myriad of presentations, ranging from an adult respiratory distress syndrome type picture to established pulmonary fibrosis. According to the current classification, pah can be associated with exposure to certain drugs or toxins such. Did you know that over 100 medications can cause adverse drug reactions that affect the lungs. Drug induced interstitial lung disease dild can be caused by chemotherapeutic agents, antibiotics, antiarrhythmic drugs, and immunosuppressive agents. Typical symptoms of these diseases include dyspnea labored breathing, chest discomfort, tachypnea rapid breathing, and hypoxemia low blood oxygen. Apr 24, 2020 drug induced disease of any system in the body is associated with a high degree of morbidity or mortality.
Clinical features are similar for most categories of cytotoxic agents, and the most common associated clinical syndrome is chronic pneumonitisfibrosis. Management of this condition generally includes immediate cessation of the offending agent and treatment with systemic corticosteroids. Mechanical ventilation in interstitial lung disease chest. Drug induced pulmonary disease is not a single disorder, but rather a common clinical problem in which a patient without previous pulmonary disease develops respiratory symptoms, chest xray changes, deterioration of pulmonary function, histologic changes, or several of these findings in association with drug therapy. Breathing problems from drug induced pulmonary fibrosis can come on suddenly, or develop more slowly over time.
Druginduced pulmonary disease is not a single disorder, but rather a common clinical problem in which a patient without previous pulmonary disease develops respiratory symptoms, chest xray changes, deterioration of pulmonary function, histologic changes, or several of these findings in association with drug therapy. Greg leader and brice labruzzo mohundro section vi drug induced cardiovascular diseases chapter 23 myocardial ischemia and acute coronary syndromes 401 kevin m. The lung is a primary target of cell injury in patients receiving cytotoxic drugs, and in many cases the reaction is severe enough to produce diffuse pulmonary fibrosis. Apr 23, 2020 did you know that over 100 medications can cause adverse drug reactions that affect the lungs. The incidence is increasing with approximately 400 drugs known to potentially cause dild. Some drugs or therapeutic agents cause undesirable reactions in lungs, known as drug induced pulmonary disease, which could be serious enough to cause death. Drug and toxin induced pulmonary arterial hypertension pah is an increasingly important subgroup of group 1 pulmonary hypertension ph. The different types of lung or pulmonary diseases caused by drugs are. Cytotoxic lung injury may result from direct injury to. Drug induced pulmonary diseases linkedin slideshare.